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KMID : 1103720080580050469
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Journal of the Korean Society of Radiology
2008 Volume.58 No. 5 p.469 ~ p.474
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The Influence of Stent Design on Neointimal Hyperplasia of an Aortic Stent Covering the Visceral Arterial Ostia: An Experimental Study in Dogs Using a Self-expandable Nitinol Stent
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Yun Young-Ho
Chung Jin-Wook
Choi Seung-Hong
Kim Kwang-Gi
Kim Hyo-Cheol
So Young-Ho
Jae Hwan-Jun
Lee Whal
Park Jea-Hyung
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Abstract
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Purpose: To assess the influence of stent design [interlacing (type A) vs. crossing method (type B)] on neointimal hyperplasia using a self-expandable nitinol stent, which crosses the side branches of the abdominal aorta.
Materials and Methods: In seven mongrel dogs, nitinol stents with type A and B intersections were placed in the abdominal aorta across the main branches: 4 Niti-Ms and 3 Niti-Ds. Two months after the stent placement, a DSA was performed for a stent patency evaluation, followed by the extraction of the aortas. The degree of neointimal formation along the wire was evaluated by calculating the area ratio of intimal hyperplasia (type A vs. B). A Student’s t-test was employed to investigate the differences in the neointimal hyperplasia between blood types A and B.
Results: The total number of wire intersections overlain at the ostia branch ostia was 23 for type A and 36 for type B. The area ratio of the neointimal hyperplasia, for a given area, was 29.09+/-10.82% (type A) and 13.80+/-6.94% (type B) (p < 0.0001)]. Furthermore, the area ratios of the neointimal hyperplasia per area of stent-wire in the given area were 138.38+/-10.84% (type A), 87.58+/-7.36% (type B) (p = 0.0002).
Conclusion: In conclusion the interlacing pattern vs. the crossing pattern showed a higher level of neointimal formation than the crossing pattern.
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KEYWORD
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Animals, Aorta, abdomina, Stents
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